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  1. General Info
  2. Effects Info
  3. Reference
Drug Details
01. General Information
Name Sodium orthovanadate
PubChem CID 61671
Molecular Weight 183.908g/mol
Synonyms

Sodium orthovanadate, 13721-39-6, Trisodium vanadate, Sodium o-vanadate, Sodium pervanadate, Sodium vanadium oxide (Na3VO4), Sodium tetraoxovanadate(3-), Sodium vanadate (ortho), Trisodium tetraoxovanadate, Vanadic acid, trisodium salt, TRISODIUM ORTHOVANADATE, Vanadic acid (H3VO4), sodium salt, trisodium trioxido(oxo)vanadium, trisodium;trioxido(oxo)vanadium, Sodium vanadate(V) (Na3VO4), 7845MV6C8V, MFCD00003511, CCRIS 9063, EINECS 237-287-9, NSC 79534, Vanadyl, UNII-7845MV6C8V, Vanadate (VO43-), trisodium, (T-4)-, AI3-52157, Vanadate(VO4(3-)), trisodium, sodiumorthovanadate, Sodium Ortho Vanadate, Na3VO4, Vanadate (VO43-), trisodium, (beta-4)-, sodium tetraoxidovanadate(V), sodium tetraoxidovanadate(3-), DTXSID2037269, CHEBI:35607, vanadate (VO4(3-)), trisodium, s2000, AKOS004910370, SODIUM ORTHOVANADATE (NA3VO4), CCG-266460, Sodium orthovanadate, >=90% (titration), FT-0688138, E75940, Sodium orthovanadate, 99.98% trace metals basis, J-006982, Q2156566

Drug Type Small molecule
Formula Na₃O₄V
SMILES [O-][V](=O)([O-])[O-].[Na+].[Na+].[Na+]
InChI 1S/3Na.4O.V/q3*+1;;3*-1;
InChIKey IHIXIJGXTJIKRB-UHFFFAOYSA-N
CAS Number 13721-39-6
ChEBI ID CHEBI:35607
TTD ID D0C6RO
Toxicity Organism Test Type Route(Dose)
rat LD50 intraperitoneal(165 mg/kg)
mouse LD50 intraperitoneal(254 mg/kg)
rat LD50 oral(322 mg/kg)
Structure 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 728
Pair Name Menadione, Sodium orthovanadate
Partner Name Menadione
Disease Info [ICD-11: 2C25] Lung cancer Investigative
Biological Phenomena Inhibition-->Cell metastasis
In Vitro Model A-549 Lung adenocarcinoma Homo sapiens (Human) CVCL_0023
Result Our data guarantee further studies to evaluate the in vivo occurrence of D-IDCs, their implications for invasiveness and metastasis and their sensitivity to anticancer drugs.
Combination Pair ID: 727
Pair Name Menadione, Sodium orthovanadate
Partner Name Menadione
Disease Info [ICD-11: 2A00] Glioblastoma multiforme Investigative
In Vitro Model DBTRG-05MG Anaplastic astrocytoma Homo sapiens (Human) CVCL_1169
Result Our results indicate that M:SO combination is an attractive alternative for glioma treatment that encourages further study. The neutralizing effects of genistein and DTT reveal a possibility for their use in the minimization of potential M:SO systemic toxicity.
03. Reference
No. Title Href
1 Menadione : sodium orthovanadate combination eliminates and inhibits migration of detached cancer cells. ISRN Pharmacol. 2012;2012:307102. doi: 10.5402/2012/307102. Click
2 Cytotoxic effect of menadione and sodium orthovanadate in combination on human glioma cells. Invest New Drugs. 2012 Aug;30(4):1302-10. doi: 10.1007/s10637-011-9680-y. Click
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